Bio. Sci. Seminar - Dr. Chen

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Virtual Event

Thursday, March 4, 2021 3 pm to 4 pm

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This is a past event.


Here is the link to see the recorded seminar of Dr. Chen.
Passcode: wnH*5=8#


Dr. Qing-Hui Chen
Associate Professor
Kinesiology and Integrative 
     Physiology Dept.
Affiliated Associate Professor,
     Biological Sciences
     Biomedical Eng.
Michigan Tech

Presentation Title: The Neural Mechanisms of Sympathetic Activation and Cardiovascular Diseases


Abstract: Elevated sympathetic outflow is an important contributor to the development of salt-sensitive hypertension (SSH) and congestive heart failure (CHF). Evidence indicates that dysfunction within the central nervous system contributes to the elevated sympathetic outflow in these cardiovascular diseases. Despite this knowledge, little is known concerning the central mechanisms responsible for the hyper-sympathetic outflow among these diseases. We have recently demonstrated that small conductance Ca2+-activated K+ (SK) channels play an important role in limiting excitability in autonomic PVN neurons and sympathetic outflow and that a reduced SK current among these PVN neurons enhance their excitability in these neurons and sympathetic outflow in SSH. To understand the cellular/molecular mechanisms of down-regulation of SK channels is an important step in developing novel approaches to decrease sympathetic outflow in SSH, which would be beneficial to the prevention and treatment of salt retention related cardiovascular diseases including SSH and CHF.



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