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Seminar zoom recording upon request-raheitor@mtu.edu
Robert Larson, PhD, MLS(ASCP)CM
Program Director—Medical Laboratory Science
Lecturer
Dept. of Biological Sciences
Michigan Tech University
Presentation Title: Targeting cardiac sensory and sympathetic nerves in hypertrophic cardiomyopathy
Abstract: Familial hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease and results in cardiac hypertrophy, myocyte disarray, fibrosis, and increased risk of arrhythmias and sudden death. Humans with HCM exhibit increased cardiac sympathetic tone in the absence of heart failure; however, the mechanism is poorly understood. To address this question, we utilized a transgenic mouse model with cardiac-specific expression of mutated alpha-tropomyosin (Glu180Gly) known to cause HCM in humans. Specific aims of this study were to characterize cardiovascular and autonomic phenotypes, and explore the mechanisms contributing to increased cardiac sympathetic tone in HCM mice. Our results show that conscious HCM mice have a cardiac-specific increase in sympathetic drive, similar to humans with HCM. In addition, we demonstrate that enhanced activity of chemosensitive cardiac afferent nerves, and reduced activity of the neuronal norepinephrine transporter in efferent cardiac sympathetic nerves both contribute to a selective increase in cardiac sympathetic tone in HCM mice.
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Zoom Link: https://michigantech.zoom.us/j/92141260056
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