This is a past event.
Here is the link for the recorded seminar:
Dr. Margret Shirinian
Department of Experimental Pathology
Immunology and Microbiology
American University of Beruit
A tale of histone and DNA modifications in brain tumors using the Drosophila melanogaster model
Abstract: Central Nervous System (CNS) tumors are the second most common cancers affecting children and adolescents after leukemia. Approximately half of these CNS tumors are childhood gliomas. Our understanding of high-grade gliomas (HGG) in children was revolutionized by the groundbreaking discovery of somatic recurrent driver mutations in Histone H3.3. Although the repertoire of cancers harboring these “oncohistones” expanded significantly the underlying molecular mechanisms affected by these Histone H3.3 mutants is still under intensive investigation. In our lab we work on unraveling the molecular mechanism through which histone and DNA modifications impact CNS development. We use Drosophila melanogaster as a model system to understand some facets of epigenetic regulation in normal development and cancer.