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Biological Science Seminar Series - Dr. Muhammad Rizwan

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Thursday, January 26, 2023, 3 pm– 4 pm

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Dr. Muhammad Rizwan

Assistant Professor

Biomedical Engineering
Michigan Technological University

 

Engineered hydrogels to control cell functions

 

Abstract: One of the long-standing goals of biomaterial design in tissue engineering is to control cell-matrix interactions and cellular functions, which ultimately lead to organized tissue formation. A major challenge in the biomaterial design is to recapitulate the biochemical and biomechanical cues present in the extracellular matrix (ECM), which drive tissue morphogenesis. This talk presents the development of biopolymer-based hydrogel, which emulate ECM features, to improve tissue engineering and organoids growth. The first application describes the development of engineered gelatin hydrogel surface with micro-nano patterns, which stimulated the proliferation and tight-junction formation of corneal endothelial monolayer, leading to a transplantable tissue formation. The second application describes the development of hyaluronan hydrogel, modified with Jagged1 ligands, to provide key biochemical and biomechanical signaling for the differentiation of liver bile duct cells and their morphogenesis into bile duct organoids in 3D cell culture. Finally, the application of light to spatially control the properties of hydrogels during cell culture is also highlighted. Collectively, our research underscores the importance of recapitulating ECM features and developmental signaling in engineered hydrogels to improve cell-matrix interactions and tissue engineering. 

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