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CATEGORIES:Academics,Lectures/Seminars
DESCRIPTION:Dr. Steven Munger\nAssociate Professor\nThe Jackson Laboratory\
 nBar Harbor\, ME\n\n \n\nThe Stories That SNPs Tell: Genetic Diversity as a
  Tool for Biological Discovery\n\n \n\nAbstract: The promise of “Precision 
 Medicine” is to leverage genome sequencing data to tailor treatment strateg
 ies to each patient’s specific disease etiology and genetic background. How
 ever\, enthusiasm for this worthwhile goal is tempered by that growing unde
 rstanding that most common diseases are highly polygenic and pleiotropic\, 
 and many adult-onset diseases likely stem at least in part from insults to 
 cell differentiation and organogenesis in utero.\n\nThis genetic and develo
 pmental complexity presents a steep challenge and points to the need for an
 imal and cell models to fully dissect the complex molecular hierarchy and t
 emporal dynamics linking genetic lesions to disease. My research program ta
 kes advantage of genetically diverse laboratory mice and stem cells\, and a
 pplies genetic mapping approaches to large\, multi-scale genomic datasets t
 o decode how segregating genetic variation perturbs gene regulatory network
 s to influence ground state pluripotency\, cell differentiation trajectorie
 s\, and adult organ function.\n\nIn my seminar\, I will present two vignett
 es that highlight the power of this integrated “systems genetics” approach 
 to reveal new biological insights. First\, we profiled quantitative liver t
 ranscriptomics and proteomics in a large population of adult outbred mice\,
  and used genetic mapping and mediation analyses to show that most of the g
 enetic variation affecting transcript abundance is buffered at the level of
  protein abundance by protein-protein interactions and stable binding in pr
 otein complexes. Second\, we derived embryonic stem cell lines (ESCs) from 
 the same population of mice\, and combined multi-omics profiling and geneti
 c mapping to trace well-known but previously uncharacterized strain differe
 nces in ESC derivation efficiency and ground state pluripotency to a single
  nucleotide variant in an enhancer region of the LIF receptor gene. Finally
 \, I will show how we are extending this powerful stem cell panel and syste
 ms genetics approaches to the field of developmental toxicology.
DTEND:20230119T210000Z
DTSTAMP:20260411T024924Z
DTSTART:20230119T200000Z
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SUMMARY:Biological Science Seminar Series - Dr. Steven Munger
UID:tag:localist.com\,2008:EventInstance_42163787384320
URL:https://events.mtu.edu/event/biological_science_seminar_series_-_dr_ste
 ven_munger
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