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VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:Biological Sciences seminar
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260721T080654Z
UID:tag:localist.com\,2008:EventInstance_2667203
DTSTART:20170317T200000Z
DTEND:20170317T210000Z
DESCRIPTION:Ashutosh Tiwari\nDepartment of Chemistry\nMichigan Technologica
 l University\n\nProtein instability\, aggregation\, and toxicity: Disulfid
 e-bond integrity holds the key\n\nProtein aggregates are hallmark of sever
 al age related disorders including neurodegenerative diseases such as Amyo
 trophic Lateral Sclerosis\, Alzheimer’s and Parkinson’s disease. Howev
 er\, the underlying mechanisms by which these aggregated proteins impair c
 ellular functions and cause toxicity is not clear. Understanding the princ
 iples and contributing factors that are expected to regulate protein misfo
 lding\, surface hydrophobic exposure\, aberrant interactions\, or aggregat
 ion is key to understanding its relationship to cellular toxicity. I will 
 discuss results from my laboratory wherein we took three proteins and stud
 ied their biochemical and biophysical properties in cellular reducing envi
 ronment and also measured cytotoxicity of the distinct aggregates in cell 
 lines.\n\n \n\nReferences:\n\nYang M\, Dutta C\, and Tiwari A. Disulfide-B
 ond Scrambling Promotes Amorphous Aggregates in Lysozyme and Bovine Serum 
 Albumin. J. Phys. Chem. B (2015) 119(10): 3969-3981. DOI: 10.1021/acs.jpcb
 .5b00144. PMID: 25689578\n\nDutta C\, Yang M\, Long F\, Shahbazian-Yassar 
 R\, and Tiwari A. Preformed Seeds Modulate Native Insulin Aggregation Kine
 tics. J. Phys. Chem. B (2015) 119(49): 15089-15099. DOI: 10.1021/acs.jpcb.
 5b07221. PMID: 26560632\n\nDorh N\, Zhu S\, Dhungana KB\, Pati R\, Luo FT\
 , Liu H\, Tiwari A. BODIPY-Based Fluorescent Probes for Sensing Protein Su
 rface-Hydrophobicity. Sci Rep. (2015) 5:18337. DOI: 10.1038/srep18337. PMI
 D: 26679512
GEO:47.119629;-88.546303
LOCATION:Dow Environmental Sciences and Engineering Building\, 642
SUMMARY:Biological Sciences seminar
URL;VALUE=URI:https://events.mtu.edu/event/biological_sciences_seminar_8261
CATEGORIES:Academics
CATEGORIES:Lectures/Seminars
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END:VCALENDAR