Biological Sciences Seminar

This is a past event.

Thursday, February 22, 2018 3 pm to 4 pm

This is a past event.

 Dr. Robert Winn, Interim Dean, College of Sciences and Arts,  Northern Michigan University and Upper Michigan Brain Tumor Center,  (http://www.nmu.edu/umbtc/staff)

The roles of Basigin and MCT-1 in Glioblastoma Multiforme

Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor in adults. Basigin (CD147/EMMPRIN) is upregulated in GBM and is known to act as a chaperone protein for the monocarboxylate transporter (MCT) family for translocation to the plasma membrane. MCT-4 is a hypoxia inducible membrane lactate transporter that has been shown to play a central role in tumor cell metabolism and proliferation and aids in removal of the lactate pool resulting from the Warburg effect.  We demonstrate the roles of basigin and MCT-4 in glioblastoma cell phenotype and will discuss their potential as therapeutic targets

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  • Joshua Gonzalez

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