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Developing a Viable Biomarker for Cells

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Thursday, April 5, 2018 1 pm

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Chemical Engineering Grain Processing Seminar Series

Dr. Tayloria Adams
Postdoctoral Research Fellow
University of California Irvine

Abstract: Stem cells have therapeutic potential to treat disease because they provide cell protection and differentiate into a variety of cell types. However, an impediment to effectively harnessing stem cells’ therapeutic potential is the inability to select specific cell subpopulations due to an insufficient number of biomarkers. Stem cell cultures are heterogeneous, containing stem cells, partially differentiated progenitor cells, and fully differentiated cells. Little is known about the defining characteristics of these progenitor cells and which are best for healing. Dielectrophoresis (DEP) is a technique that uses electric fields to characterize and separate cells based on the dielectric properties of their membrane and cytoplasm. Membrane capacitance is a promising biomarker that is quantifiable via DEP. This work focuses on effectively characterizing and sorting progenitor cells present in mesenchymal and neural stem cell populations using DEP to advance the development of membrane capacitance as a reliable label-free biomarker.

Bio: Dr. Tayloria Adams graduated from Virginia Commonwealth University with a B.S. in Chemical and Life Science Engineering and a B.S. in Applied Mathematics. She earned her M.S. and Ph.D. in Chemical Engineering from Michigan Technological University (MTU). Her doctoral research examined human mesenchymal stem cells’ dielectric behavior for cell sorting in microfluidic devices. She published 3 peer-reviewed journal articles from her graduate work and also has a patent for a handheld dielectrophoresis device to analyze blood samples. Now, Dr. Adams is a postdoctoral research fellow at the University of California Irvine (UCI) where she studies the dielectric and differentiation properties of neural stem cells for the development of stroke therapies using microfluidic technology. She is a NSF Postdoctoral Research Fellowship and UCI Chancellor’s ADVANCE Postdoctoral Fellowship recipient and past GEM Fellowship recipient. Dr. Adams is an active member of the National Society of Black Engineers, Society of Women Engineers and AES Electrophoresis Society (2017 Annual Meeting Organizer).

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