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Engineered Hydrogels for the Differentiation and Organoids Growth of Liver Cells

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Friday, April 15, 2022, 3:30 pm

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BioMed Graduate Seminar

Muhammad Rizwan

Assistant Professor, Biomedical Engineering
Michigan Technological University

Abstract

Diseases specific to liver bile duct cells (cholangiocytes) account for 70% of pediatric and up to a third of adult liver transplantations. Cholangiocyte can be used to model liver biliary diseases and for transplantation. Notch signaling and a favorable extracellular microenvironment is critical to differentiate human stem cells to cholangiocytes and for primary cholangiocyte organoid growth. This talk describes the development of engineered Notch activating hyaluronan (HA) hydrogels to specifically differentiate human embryonic stem cell-derived hepatoblasts to cholangiocytes and photo-chemical control of Notch signaling.

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