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Biomedical Engineering Seminar

Amit Jaiswal, PhD

School of Basic Sciences
Indian Institute for Technology Mandi, India

Abstract

The recent development in the design and synthesis of novel plasmonic nanostructures have drawn significant attention due to their variety of applications in sensing, catalysis, photonics and theranostics. In this context, we engineered different metal nanorattle structures having a solid Au as core and a thin porous rod-shaped shell with extinction in both NIR-I and NIR-II regions. The unique properties of these plasmonic structures such as porous nature, intrinsic EM hotspots and broad absorption in the NIR region were utilized in designing a stimulus responsive nanotheranostic system capable of SERS based bioimaging and sensing. In addition, the nanorattles showed superior SERS sensing ability in detecting trace analytes upto 1 fM (S/N ratio > 4). We further fabricated different flexible cellulose and polymeric film-based SERS substrates and demonstrated its ability to sense trace molecules. In the present talk, I will be discussing about surface plasmon resonance and how does it get affected by the size and shape of metal nanostructures leading to tuneable absorbance ranging from visible to NIR region. Next, I will discuss the applications of NIR active nanorattles in photothermal therapy and SERS.

The schematic shows the synthesis of rattle like plasmonic nanocapsules and their corresponding TEM images.