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Fate and Transport of Emerging Organic Contaminants in the Great Lakes Environment and the Identification of Biomarkers of Carcinogens Associated with Tobacco Exposure

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Monday, September 27, 2021 3 pm

This is a past event.

Joint Environmental Engineering Graduate and Chemistry Seminar

Jiehong Guo, Masonic Cancer Center, University of Minnesota

Abstract: Emerging organic contaminants (such as flame retardants, plasticizers, etc.) are widely present in the environment and may cause adverse health effects on human. Several activities have been conducted to investigate the fate and transport of these chemicals in the Great Lakes, including examining the spatial and temporal trends in the sediment, tributary loading to Lake Michigan, bioaccumulation in the fish and eagle, as well as investigating phases partitioning, in situ degradation and potential sources. Previously unknown organohalogens, such as polyhalogenated carbazoles (PHCZs), Marbon or other flame retardants, have been discovered in sediment, water or dust during the routine analysis of regular flame retardants. These chemicals may cause similar environmental concern as known compounds. To identify biomarkers of human exposure to carcinogens, methods were developed to quantify DNA damage induced by formaldehyde and tobacco-specific nitrosamines in rat tissues, smokers and/or e-cigarette users. More researches are needed to further understand the source, fate and toxicity of organic contaminants.

Bio: Dr. Jiehong Guo is currently a Researcher 6 at University of Minnesota Twin Cities (UMN). She has previously worked in Indiana University Bloomington as a Postdoctoral Research Associate. She obtained her Ph.D. in Public Health from the University of Illinois at Chicago, M.S. in Environmental Engineering and B.S. in Bioengineering. In UMN, She works in identifying biomarkers of DNA damage caused by tobacco-associated carcinogens using mass spectrometric approach. Before that, her research has focused on developing and applying analytical methods to measure persistent, bioaccumulative and toxic (PBT) pollutants in various environmental matrices, evaluating the magnitude of environmental pollution, and examining the fate and transport of PBT chemicals in the Great Lakes environment. Dr. Guo has published 30 peer-reviewed papers and was listed as first author in 16 of them.

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