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Investigation of Metallic Biodegradable Cardiovascular Materials at the Cell and Tissue-material Interface

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Wednesday, January 29, 2020 10 am

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Biomedical Engineering Graduate Seminar

The Department of Biomedical Engineering presents

Roger Guillory, PhD

Postdoctoral Scholar
Northwestern University

Abstract: Inadequate mitigation of long-term permanent stent outcomes has generated an intense interest for exploring alternative engineering solutions. The most promising alternative approach is to develop a metallic stent that is completely and safely absorbed over time. Over the past 20 years, the field of biomaterials has witnessed a fevered introduction of degradable materials including metals, polymers, composites, additively manufactured matrices, and natural substrates. In 2013, zinc was introduced as a candidate degradable material for cardiovascular stents. In order to develop successful zinc-based materials, a thorough understanding of the cell-tissue material interactions and the resulting biologic response is essential. The present work explores the biological effects elicited by zinc-based materials implanted within the murine arterial system. The biological effects of degradable arterial zinc based implants were characterized by quantitative histomorphometry, recruited inflammatory cell presence, and in-situ protein expression. The effect of implanted material characteristics including surface oxide film stability, elemental composition, and microstructure were interrogated by probing the consequential biologic response due to these changes. Additionally, the biocompatibility of novel zinc silver alloys was determined for use as next generation degradable stent materials. This work places degradable materials in a biologic context that informs future metallurgical and surface design of material candidates. Furthermore, understanding the cell-tissue material interface of degradable materials is of paramount importance, and contributes to the proper design of biodegradable metallic materials.

Location: To find M&M 610, cross over Cliff Drive to the canal side and enter under the skywalk. The 6th floor is level with Cliff Drive.

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