KIP April Seminar: Dr. Caroline Rickards
Caroline Rickards, PhD
Department of Physiology & Anatomy
University of North Texas
Presentation Title: Take a Deep Breath...The Role of Breathing on Brain Blood Flow Regulation
Abstract: Respiratory-induced changes in arterial blood gases and acid-base balance have a profound effect on cerebral blood flow regulation. An under-explored effect of breathing on cerebral blood flow is the modulation of intrathoracic pressure. Inspiratory resistance breathing is a therapeutic approach that augments the reduction in intrathoracic and intracranial pressure during inspiration, facilitating improvements in vital organ perfusion under conditions of ischemia, such as blood loss and cardiac arrest. In this seminar, I will present a series of studies assessing the role of inspiratory resistance breathing on responses of cerebral blood flow and cerebral tissue oxygenation under conditions of actual blood loss in animal models, and simulated hemorrhage in humans. Knowledge gaps in this field of investigation will be presented, and future research directions will be discussed.
Biography: Dr. Rickards is an Associate Professor in the department of Physiology & Anatomy at the University of North Texas Health Science Center. She obtained her PhD in 2005 in the Aerospace Physiology Laboratory, School of Medical Sciences at RMIT University in Melbourne, Australia. She is currently the principal investigator on a number of projects, including a grant through the American Heart Association for her research on improving cerebral tissue blood flow and oxygenation via pulsatile perfusion therapy. Some of her other research projects include the study of vascular function following blood flow restriction exercise training, and pyruvate-enriched resuscitation to reduce inflammation and free radical production during simulated hemorrhage. She currently teaches Physiology in Health and Disease, Topics in Biomedical Sciences and Integrative Biomedical Sciences I: Physiology at the University of North Texas Health Science Center.
Friday, April 26 at 3:00 pm to 4:00 pm
Advanced Technology Development Complex (ATDC), 101
1400 Townsend Drive, Houghton, MI 49931