KIP November Seminar: Dr. Megan Frost and Dr. Caroline Gwaltney


Megan Frost, PhD
Department of Kinesiology and Integrative Physiology
Department of Biomedical Engineering
Michigan Technological University

Caroline Gwaltney, PT, DPT, CWS
Physical Therapy Program
Central Michigan University  

Presentation Title: The Need for Understanding Real-Time Nitric Oxide (NO) Release for the Development of Smart Dressings for Diabetic Foot Ulcers

Abstract: Diabetes Mellitus is a metabolic disorder that effects 29.1 million Americans. This disease and its complications created $245 billion in health care costs in the US in 2012. It is estimated that approximately 15% of those suffering from diabetes will also suffer from chronic foot ulcers that develop as a result of the so called “pathogenic triad of neuropathy, ischemia and trauma”. Additionally, infections in these open wounds further complicates this classical triad and makes treatment of foot ulcers even more challenging. Chronic foot ulcers result in open wounds that do not heal for more then 128 days, and in fact grow in size over time, thereby causing increased morbidity and mortality for those afflicted with these wounds. We are systematically investigate cellular response of macrophages, fibroblasts and keratinocytes to nitric oxide delivered with temporal and spatial control. Dysfunction in the regulation of these cell populations has been shown to be an underlying cause of diabetic ulcers. Understanding how these cells respond to precisely delivered doses and durations of NO will allow engineering of smart wound dressings which solve a significant health problem. The goal is to move wound healing through inflammation and into the migration and proliferation stages to lead to complete wound resolution in 21 days.

Biography: Dr. Megan Frost is Interm Department Chair of Kinesiology and Integrative Physiology and Professor in Biomedical Engineering at Michigan Tech. Her research focuses on the development of polymeric materials that exhibit improved biocompatibility when implanted in living organisms and using these materials to fabricate implantable sensors that function for extended time periods (i.e., longer than 24 h). 

Dr. Caroline Gwaltney is Assistant Professor and Regional Clinical Coordinator in Central Michigan University's Doctor of Physical Therapy program extension at Michigan Tech. Her research includes the role of nitric oxide on macrophage, fibroblast, and keratinocyte mobility in normal and diabetic conditions. She obtained her Doctor of Physical Therapy at the College of St. Scholastica in 2017. 

Audience: Everyone welcome, students strongly encouraged to attend. 
Refreshments provided and no registration necessary. 

Friday, November 9, 2018 at 3:00 pm to 4:00 pm

Advanced Technology Development Complex (ATDC), 101
1400 Townsend Drive, Houghton, MI 49931

Event Type

Academics, Lectures/Seminars

Target Audience

Students, Graduate, Undergraduate, Faculty/Staff, General Public

Subscribing Departments ?
Biomedical Engineering, Kinesiology and Integrative Physiology
Host ?

Kinesiology & Integrative Physiology


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