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Materials with Multi‐Scale Structure for Biomedical Applications

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Thursday, April 18, 2019, 4 pm

This is a past event.

ME-EM Graduate Seminar Speaker Series

proudly presents:

Parisa Abadi, PhD

Michiagan Technological University

Abstract: Materials with multi‐scale structure have many applications. In this presentation, two of the applications will be shown: carbon nanotube‐based nano‐bioactuators and cardiomyocyte tissue engineering. In the first part, microfibers composed of hyaluronic acid hydrogel and single‐wall carbon nanotubes are developed for biocompatible electrochemical microactuators. Mechanically robust, flexible, and electrically conductive microfibers are obtained by wet‐spinning and crosslinking of the hybrid fiber. The obtained hybrid microfibers show excellent conductivity, capacitance, and actuation behavior under low potential in a biological environment. In the second part, PDMS substrates with 3D topography at the micron and sub‐micron levels are developed and used as cell‐culture substrates to mimic the biophysical and biomechanical complexity of the native in vivo environment during the differentiation and maturation process of cardiomyocytes derived from induced pluripotent stem cells. The resulting cardiomyocytes exhibit a more mature phenotype than control groups and exhibit the shape and orientation of mature cardiomyocytes in human myocardium.

Bio: Dr. Abadi is an Assistant Professor of Mechanical Engineering‐Engineering Mechanics at Michigan Tech. She received her PhD in Mechanical Engineering from Georgia Institute of Technology. Prior to joining Michigan Tech, she was a NIH Postdoctoral Research Fellow at Harvard Medical School, Brigham and Women's Hospital. Her research interests are in the areas of nanomaterials and mechanics and their applications in tissue engineering and medical devices. She is a 2017 recipient of a Scientist Development Grant from the American Heart Association.

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