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Polymeric Biomaterials for Protein Therapy and Bioresorbable Synthetic Grafts

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Friday, September 17, 2021 3:00pm to 5:00pm

This is a past event.

Biomedical Engineering Seminar

Xiaochu Ding, PhD

Department of Chemistry
Michigan Tech University

Abstract

Polymeric biomaterials have advantages of controllable structure and properties, reproducibility and cost-effectiveness for biomedical applications. Therefore, they have played important roles in medical devices and regenerative medicine. In this topic, I will introduce my research with a tie between polymer science and tissue regeneration.

In the first part, I will introduce how to design protein delivery platforms by utilizing natural affinity of heparin to protein protection. The designed delivery platforms can sustainably release heparin-binding proteins with a stabilized structure against proteolysis, and thus enhance therapeutic efficiencies as demonstrated by strong angiogenesis in vivo. In the second part, I will discuss the design of biodegradable and bioresorbable elastomers that are used to engineer resorbable synthetic grafts, a porous conduit for replacement of occlusive small arteries (diameter < 6 mm). The conduit is implanted in a rat carotid artery interposition model for in situ remodeling to generate a native artery-like blood vessel as the polymer is degraded and absorbed by host cells. No complications such as thrombosis, intimal hyperplasia, or infection are observed in the remodeled grafts. In addition, I will also summarize the limitations of the previous designs and propose new solutions for both protein delivery and synthetic grafts.

Additional Details

Location

Map of Minerals and Materials Engineering Building (M&M)

Address

  • Joanie Slosar

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